Description

2-(1-Boc-3-Piperidinylidene)Acetonitrile is a versatile and high-value synthetic intermediate used in advanced organic synthesis. Its primary value lies in its role as a key building block for constructing complex nitrogen-containing heterocycles, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within the fields of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Process Chemistry Development: Serves as a key starting material for scaling up the production of complex piperidine-based molecules under GMP conditions.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates for client projects.
• Agrochemical Research: Potential application in the development of new crop protection agents and pesticides that require specific nitrogen heterocycle scaffolds.
• Academic & Institutional Research: Used in university and institutional labs for methodological development in organic synthesis and catalysis.

Basic Information

Product Name	2-(1-Boc-3-Piperidinylidene)Acetonitrile
CAS No.	1159982-27-0
Molecular Formula	C₁₂H₁₈N₂O₂
Molecular Weight	222.28 g/mol
Synonyms	2-(1-[(tert-Butoxy)carbonyl]-3-piperidinylidene)acetonitrile; 1-Boc-3-(cyanomethylene)piperidine; tert-Butyl 3-(cyanomethylene)piperidine-1-carboxylate; 3-(Cyanomethylene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-(cyanomethylene)-1-piperidinecarboxylate; Boc-3-(cyanomethylene)piperidine; 2-(1-Boc-3-piperidylidene)acetonitrile; (1-Boc-3-piperidinylidene)acetonitrile
EINECS	Contact for details

Quality Control

Our 2-(1-Boc-3-Piperidinylidene)Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.