Description

Palmitoyl Ethanolamide-D4 is a deuterium-labeled analog of the endogenous fatty acid amide, palmitoylethanolamide (PEA). This stable isotope-labeled compound is essential for quantitative mass spectrometry analysis, providing critical internal standards for accurate bioanalytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of endogenous PEA in biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug metabolism and absorption rates in preclinical and clinical research involving PEA or related compounds.
• Biomarker Research: Used in the development and validation of assays to study PEA as a potential biomarker for various inflammatory and neurological conditions.
• Method Development and Validation: Essential for establishing robust, accurate, and reproducible analytical methods in compliance with Good Laboratory Practice (GLP) and other regulatory guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for pharmaceutical products containing or targeting the endocannabinoid system.

Basic Information

Product Name	Palmitoyl Ethanolamide-D4
CAS No.	1159908-45-8
Molecular Formula	C₁₈H₃₁D₄NO₂
Molecular Weight	305.50 g/mol
Synonyms	N-(2-Hydroxyethyl)hexadecanamide-d4; Palmitoylethanolamide-d4; PEA-d4; N-Palmitoylethanolamine-d4; N-(2-Hydroxyethyl)palmitamide-d4; Deuterated Palmitoylethanolamide; [D4]-PEA; N-Hexadecanoylethanolamine-d4
EINECS	Contact for details

Quality Control

Our Palmitoyl Ethanolamide-D4 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (atom % D), and chromatographic profile. We adhere to industry best practices, and specifications can be tailored to meet specific research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.