Description

2-Chloro-n-((3S,4S)-4-Hydroxy-1-Tosylpyrrolidin-3-Yl)-n-((R)-1-Phenylethyl)Acetamide is a sophisticated chiral intermediate featuring a complex molecular architecture with defined stereocenters. This compound is of significant value in the research and development of novel pharmaceutical agents, particularly as a key building block for active pharmaceutical ingredients (APIs) and complex organic syntheses. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of potential drug candidates, especially in medicinal chemistry programs.
• API Development: Used as a building block for the construction of complex molecules targeting specific biological pathways, such as enzyme inhibitors or receptor modulators.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce defined chiral elements into more complex molecular frameworks.
• Chemical Research: Utilized in academic and industrial research for exploring new synthetic methodologies and reaction mechanisms involving amide and pyrrolidine chemistry.
• Process Chemistry: Investigated for scale-up and optimization in the development of efficient, cost-effective manufacturing routes for advanced intermediates.

Basic Information

Product Name	2-Chloro-n-((3S,4S)-4-Hydroxy-1-Tosylpyrrolidin-3-Yl)-n-((R)-1-Phenylethyl)Acetamide
CAS No.	1159908-19-6
Molecular Formula	C21H25ClN2O4S
Molecular Weight	436.95 g/mol
Synonyms	2-Chloro-N-[(3S,4S)-4-hydroxy-1-(4-methylphenyl)sulfonylpyrrolidin-3-yl]-N-[(1R)-1-phenylethyl]acetamide; (3S,4S)-N-(1-Phenylethyl)-N-[2-chloroacetyl]-4-hydroxy-1-tosylpyrrolidine-3-carboxamide; 2-Chloro-N-((3S,4S)-4-hydroxy-1-tosyl-3-pyrrolidinyl)-N-((1R)-1-phenylethyl)acetamide; 1159908-19-6; Chiral Pyrrolidine Tosylamide Derivative; (R,S)-Configured Acetamide Intermediate.
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-((3S,4S)-4-Hydroxy-1-Tosylpyrrolidin-3-Yl)-n-((R)-1-Phenylethyl)Acetamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC), identity confirmation (NMR, IR), and determination of chemical purity and related substances to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.