Description

1-Piperazinecarboxylic Acid, 2-Methyl-, 9H-Fluoren-9-Ylmethyl Ester, Hydrochloride (1:1) is a high-purity, protected amino acid derivative primarily used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular control in the development of complex molecules. It is particularly valuable for the pharmaceutical and biotechnology industries in the synthesis of peptide-based drugs, active pharmaceutical ingredients (APIs), and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block, facilitating the controlled assembly of peptide chains.
• Protecting Group Strategy: The 9-fluorenylmethyloxycarbonyl (Fmoc) group provides orthogonal protection for the piperazine nitrogen, enabling selective deprotection in complex synthetic sequences.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Chemical Biology: Employed in the synthesis of labeled probes, molecular tools, and modified peptides for biochemical and cellular studies.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 2-Methyl-, 9H-Fluoren-9-Ylmethyl Ester, Hydrochloride (1:1)
CAS No.	1159826-45-5
Molecular Formula	C21H24N2O2 • HCl
Molecular Weight	372.89 g/mol
Synonyms	Fmoc-2-methylpiperazine hydrochloride; (2-Methylpiperazin-1-yl)(9H-fluoren-9-yl)methanone hydrochloride; 9-Fluorenylmethyl N-(2-methylpiperazine-1-carbonyl)carbamate hydrochloride; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylpiperazine hydrochloride; 2-Methyl-1-piperazinecarboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride; Fmoc-2-Me-Pip-OH • HCl; Nα-Fmoc-2-methylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 1-Piperazinecarboxylic Acid, 2-Methyl-, 9H-Fluoren-9-Ylmethyl Ester, Hydrochloride (1:1) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.