Description

3-Boc-Amino-3-Oxetanecarboxylic Acid CAS NO 1159736-25-0 is a high-purity, protected amino acid derivative featuring a versatile oxetane ring. This compound is a critical building block in modern pharmaceutical research and development, enabling the synthesis of complex molecules with improved metabolic stability and physicochemical properties. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small molecule drug candidates.
• Peptide Mimetics & Conformationally Restricted Peptides: Used to incorporate the rigid oxetane scaffold into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• PROTAC (Proteolysis Targeting Chimera) Linker Chemistry: Serves as a component in the design of E3 ligase ligands or linkers for targeted protein degradation platforms.
• Bioconjugation & ADC (Antibody-Drug Conjugate) Payload Synthesis: Employed to construct specialized linkers or functionalized payload molecules for targeted cancer therapies.
• Chemical Biology Probes: Used to develop activity-based probes and molecular tools for studying enzyme function and cellular pathways.
• Agrochemical Research: Acts as a building block for developing novel herbicides and fungicides with unique modes of action.

Basic Information

Product Name	3-Boc-Amino-3-Oxetanecarboxylic Acid
CAS No.	1159736-25-0
Molecular Formula	C9H15NO5
Molecular Weight	217.22 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]oxetane-3-carboxylic Acid; 3-(Boc-amino)oxetane-3-carboxylic Acid; 3-(tert-Butoxycarbonylamino)-3-oxetanecarboxylic Acid; 3-[(tert-Butoxycarbonyl)amino]-3-oxetanecarboxylic Acid; 3-Boc-Aminooxetane-3-carboxylic Acid; Boc-Amino-oxetane-3-carboxylic Acid; 3-(Boc-amino)-3-oxetane carboxylic acid; tert-Butyl (3-carboxyoxetan-3-yl)carbamate
EINECS	Contact for details

Quality Control

Our 3-Boc-Amino-3-Oxetanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.