Description

2-Fluoro-3-(Trifluoromethoxy)Phenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. This compound is critical for introducing specific fluorine-containing motifs that can dramatically alter the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its unique structure enables fine-tuning of metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays, leveraging its aromatic core and fluorine atoms to modify dielectric anisotropy and viscosity.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethoxy)Phenylacetic Acid
CAS No.	1159512-61-4
Molecular Formula	C9H6F4O3
Molecular Weight	238.14 g/mol
Synonyms	[2-Fluoro-3-(trifluoromethoxy)phenyl]acetic acid; 2-(2-Fluoro-3-(trifluoromethoxy)phenyl)acetic acid; α-(2-Fluoro-3-(trifluoromethoxy)phenyl)acetic acid; 2-Fluoro-3-(trifluoromethoxy)benzeneacetic acid; 1159512-61-4; FTFA; 2-F-3-TFMPAA
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-(Trifluoromethoxy)Phenylacetic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring compliance with your research or production specifications. Our standard grade meets high-purity requirements typical for advanced intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.