Description

3-(Difluoromethyl)Phenylacetylene is a high-value, multi-functional aromatic alkyne building block distinguished by its difluoromethyl substituent. This compound is essential for introducing both the rigid acetylene linkage and the metabolically stable difluoromethyl group into target molecules, enabling the synthesis of advanced materials and bioactive compounds. It is primarily sought by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics where the difluoromethyl group improves metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and plant growth regulators, leveraging the fluorine atoms for enhanced biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers, liquid crystals, and organic electronic materials requiring conjugated systems with fluorinated aromatic units.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems or complex molecular frameworks.
• Click Chemistry: Utilized in Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) reactions for bioconjugation, polymer functionalization, and library synthesis in drug discovery.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorination on physical, chemical, and biological properties of organic compounds.

Basic Information

Product Name	3-(Difluoromethyl)Phenylacetylene
CAS No.	1159512-57-8
Molecular Formula	C9H6F2
Molecular Weight	152.14 g/mol
Synonyms	3-(Difluoromethyl)phenylacetylene; 1-Ethynyl-3-(difluoromethyl)benzene; 3-Ethynyl-α,α-difluorotoluene; m-(Difluoromethyl)phenylacetylene; (3-(Difluoromethyl)phenyl)ethyne; 1159512-57-8; 3-DFMPA
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Phenylacetylene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.