Description

(S)-tert-Butyl (1-Cyano-2-(4-Iodophenyl)Ethyl)Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex bioactive molecules, offering a defined stereocenter and protected amine functionality for precise chemical transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetic Research: Serves as a protected amino acid derivative for constructing peptide analogs and mimetics with enhanced metabolic stability.
• Asymmetric Synthesis: Used in catalytic asymmetric reactions to introduce chiral complexity into target molecular architectures.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns for drug discovery programs.
• Chemical Biology Probes: Acts as a precursor for labeled compounds or molecular probes used in biochemical and cellular assays.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(S)-tert-Butyl (1-Cyano-2-(4-Iodophenyl)Ethyl)Carbamate
CAS No.	1159489-37-8
Molecular Formula	C₁₄H₁₇IN₂O₂
Molecular Weight	372.20 g/mol
Synonyms	(S)-tert-Butyl 1-cyano-2-(4-iodophenyl)ethylcarbamate; (S)-Boc-4-iodo-phenylalaninenitrile; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-iodophenyl)propanenitrile; (S)-N-Boc-4-iodo-DL-phenylalaninenitrile; Boc-(S)-4-Iodo-Phe(CN)-OH; tert-Butyl N-[(1S)-1-cyano-2-(4-iodophenyl)ethyl]carbamate; (S)-Boc-4-I-Phe(CN)-OH; (S)-1-((tert-Butoxycarbonyl)amino)-2-(4-iodophenyl)ethane-1-carbonitrile
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl (1-Cyano-2-(4-Iodophenyl)Ethyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.