Description

1-(4-Nitrobenzoyl)Piperidin-4-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1158368-56-9. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly for neurological and oncological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery laboratories.
• Chemical Synthesis Building Block: Serves as a versatile amine-containing synthon for constructing more complex heterocyclic and amide-based molecular frameworks.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Biochemical Research: Potential use in the development of enzyme inhibitors or receptor ligands for biochemical assays.

Basic Information

Product Name	1-(4-Nitrobenzoyl)Piperidin-4-Amine Hydrochloride
CAS No.	1158368-56-9
Molecular Formula	C12H16N3O3·HCl
Molecular Weight	285.74 g/mol
Synonyms	4-Amino-1-(4-nitrobenzoyl)piperidine hydrochloride; 4-Amino-N-(4-nitrophenyl)piperidine-1-carboxamide hydrochloride; 1-(4-Nitrobenzoyl)-4-aminopiperidine HCl; 4-Nitro-N-(4-aminopiperidin-1-yl)benzamide hydrochloride; Piperidin-4-amine, 1-[(4-nitrophenyl)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 1-(4-Nitrobenzoyl)Piperidin-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.