Description

2-(4-(Trifluoromethoxy)Phenyl)Cyclopropanecarboxylic Acid is a high-value, multifunctional organic building block characterized by its cyclopropane ring and trifluoromethoxy-substituted aromatic system. This compound matters for its unique combination of structural rigidity and lipophilicity imparted by the fluorine atoms, making it a critical intermediate in advanced synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Material Science Research: Used in the synthesis of specialty monomers and polymers to impart specific chemical resistance and thermal properties.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorinated groups on molecular conformation and reactivity.
• Liquid Crystal & OLED Materials: Potential intermediate for electronic chemicals used in display and lighting technologies due to its aromatic and rigid structure.

Basic Information

Product Name	2-(4-(Trifluoromethoxy)Phenyl)Cyclopropanecarboxylic Acid
CAS No.	1157562-31-6
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	2-[4-(Trifluoromethoxy)phenyl]cyclopropanecarboxylic acid; 2-(4-Trifluoromethoxyphenyl)cyclopropanecarboxylic Acid; α-(4-Trifluoromethoxyphenyl)cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-[4-(trifluoromethoxy)phenyl]-; 1157562-31-6; 2-(4-(Trifluoromethoxy)phenyl)cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(4-(Trifluoromethoxy)Phenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.