Description

n-(4-Cyano-2-Nitro-5-(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroacetamide is a high-value, multi-functionalized aromatic intermediate featuring both cyano and nitro groups on a trifluoromethylphenyl backbone. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique trifluoromethyl and electron-withdrawing substituents impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the fine chemical, agrochemical, and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of next-generation herbicides, insecticides, and fungicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring compounds with high lipophilicity and stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Synthesis: Acts as an intermediate for creating specialized dyes and pigments where nitro and cyano groups contribute to color and fastness properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Chemical Synthesis Reference Standard: Employed as a high-purity analytical standard for quality control and method development in chemical manufacturing.

Basic Information

Item	Details
Product Name	n-(4-Cyano-2-Nitro-5-(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroacetamide
CAS No.	1155800-48-8
Molecular Formula	C10H3F6N3O3
Molecular Weight	327.14 g/mol
Synonyms	2,2,2-Trifluoro-N-[4-cyano-2-nitro-5-(trifluoromethyl)phenyl]acetamide; N-(4-Cyano-2-nitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoroacetamide, N-[4-cyano-2-nitro-5-(trifluoromethyl)phenyl]-; 1155800-48-8; 4-Cyano-2-nitro-5-(trifluoromethyl)aniline, N-trifluoroacetyl derivative; TFAPA derivative; Trifluoroacetylamino-nitro-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our n-(4-Cyano-2-Nitro-5-(Trifluoromethyl)Phenyl)-2,2,2-Trifluoroacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.