Description

tert-Butyl 3-Hydroxy-3-(2-Hydroxyethyl)Azetidine-1-Carboxylate is a versatile and high-value azetidine derivative, serving as a critical building block in modern synthetic organic chemistry. Its bifunctional nature, featuring both a protected amine and two hydroxyl groups, makes it an essential intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its unique scaffold enables the development of compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small-molecule drugs, particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific stereochemical configurations.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Construction: The azetidine ring is a valuable bioisostere, making this compound useful for designing peptide analogs and other bioactive compounds.
• Material Science Research: Employed in the synthesis of specialized monomers for advanced polymers with tailored properties.
• Custom Synthesis and Contract Manufacturing: A high-purity starting material for custom synthesis projects in CDMO (Contract Development and Manufacturing Organization) settings.

Basic Information

Product Name	tert-Butyl 3-Hydroxy-3-(2-Hydroxyethyl)Azetidine-1-Carboxylate
CAS No.	1154760-04-9
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	1-Boc-3-hydroxy-3-(2-hydroxyethyl)azetidine; 3-Hydroxy-3-(2-hydroxyethyl)azetidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-hydroxy-3-(2-hydroxyethyl)azetidine; tert-Butyl 3-hydroxy-3-(2-hydroxyethyl)azetidine-1-carboxylate; Azetidine-1-carboxylic acid, 3-hydroxy-3-(2-hydroxyethyl)-, 1,1-dimethylethyl ester; 3-(2-Hydroxyethyl)-3-hydroxyazetidine-1-carboxylic acid tert-butyl ester; Boc-3-hydroxy-3-(2-hydroxyethyl)azetidine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this high-value intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, ensuring batch-to-batch consistency and traceability. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.