Description

(4S)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-5,5-Dimethyl-4-(1-Methylethyl)-Oxazole is a high-value, chiral phosphine-oxazoline (PHOX) ligand, a critical class of organocatalysts in asymmetric synthesis. Its importance lies in its ability to induce high enantioselectivity in a variety of transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds essential for advanced materials and pharmaceuticals. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel synthetic pathways and optimizing manufacturing processes for chiral intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and alcohols.
• Catalyst component in asymmetric allylic substitution reactions to form carbon-carbon and carbon-heteroatom bonds with high stereocontrol.
• Employed in asymmetric hydroboration and hydrosilylation processes for the preparation of chiral organoboron and organosilicon compounds.
• Use in asymmetric cross-coupling reactions, such as Heck, Suzuki, and Buchwald-Hartwig aminations, to construct complex chiral molecules.
• Critical for academic and industrial research in developing new catalytic methodologies and exploring novel chemical space.
• Potential application in the synthesis of active pharmaceutical ingredients (APIs) and key chiral intermediates for drug candidates.

Basic Information

Product Name	(4S)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-5,5-Dimethyl-4-(1-Methylethyl)-Oxazole
CAS No.	1152313-76-2
Molecular Formula	C26H28NOP
Molecular Weight	401.48 g/mol
Synonyms	(S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)oxazole; (S)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole; (S)-t-Bu-PHOX; (S)-tert-ButylPHOX; PHOX Ligand; Chiral PHOX Ligand; (S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Our production of (S)-t-Bu-PHOX ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized using advanced analytical techniques including NMR (¹H, ³¹P, ¹³C), HPLC for chiral purity, and elemental analysis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to minimize oxidation and degradation. The container should be kept tightly sealed in a desiccator to prevent moisture uptake. Allow the sealed container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
³¹P NMR Purity	Conforms
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.