Description

(2S)-3-[4-({[(2,2-Dichloroethenyl)Oxy]Sulfonyl}Oxy)Phenyl]-Fmoc-2-Aminopropanoic Acid is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and chemical biology research. This compound matters as a key building block for introducing the unique 4-(2,2-dichlorovinyloxy)sulfonyloxy phenylalanine moiety into peptide chains, enabling the study of post-translational modifications or creating novel bioactive structures. It is primarily needed by pharmaceutical R&D teams, peptide synthesis service providers, and academic research groups focused on developing new therapeutic peptides and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a specialized, side-chain protected Fmoc-amino acid for the automated synthesis of complex peptides.
• Chemical Biology Tool Development: Used to incorporate a chemically reactive or cleavable group into peptides for studying protein-protein interactions or enzyme activity.
• Pharmaceutical Intermediate: Acts as a critical precursor in the research and development stages of novel peptide-based drug candidates.
• Bioconjugation: The unique sulfonyloxy-dichloroethenyl side chain can be leveraged for site-specific conjugation with other molecules, such as fluorophores or drug payloads.
• Proteomics Research: Employed in the synthesis of affinity tags or activity-based probes for mass spectrometry and proteomic analysis.
• Material Science: Potential use in creating peptide-based polymers or surfaces with specific chemical functionalities.

Basic Information

Product Name	(2S)-3-[4-({[(2,2-Dichloroethenyl)Oxy]Sulfonyl}Oxy)Phenyl]-Fmoc-2-Aminopropanoic Acid
CAS No.	1151854-06-6
Molecular Formula	C26H21Cl2NO8S
Molecular Weight	578.42 g/mol
Synonyms	Fmoc-Tyr(SO2OCH=CCl2)-OH; Fmoc-O-(2,2-dichlorovinylsulfonyl)-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[((2,2-dichloroethenyl)oxy)sulfonyl]-L-tyrosine; Fmoc-L-tyrosine(2,2-dichlorovinyl sulfonate); (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[4-({[(2,2-dichloroethenyl)oxy]sulfonyl}oxy)phenyl]propanoic acid; Fmoc-Tyr(SO2-O-DCV)-OH; 4-({[(2,2-Dichloroethenyl)oxy]sulfonyl}oxy)-L-phenylalanine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of (2S)-3-[4-({[(2,2-Dichloroethenyl)Oxy]Sulfonyl}Oxy)Phenyl]-Fmoc-2-Aminopropanoic Acid is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to guarantee identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request. We adhere to cGMP principles for manufacturing critical pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.