Description

4-Fluorotetrahydro-2H-Pyran-4-Carboxylic Acid is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of both a fluorine atom and a carboxylic acid functional group within a saturated pyran ring, enabling precise modulation of molecular properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored surface properties and stability.
• Fluorine Chemistry Building Block: Essential for introducing the tetrahydropyran scaffold with a fluorinated quaternary center into more complex molecular architectures.

Basic Information

Product Name	4-Fluorotetrahydro-2H-Pyran-4-Carboxylic Acid
CAS No.	1150617-62-1
Molecular Formula	C6H9FO3
Molecular Weight	148.13 g/mol
Synonyms	4-Fluorotetrahydro-2H-pyran-4-carboxylic acid; 4-Fluorotetrahydropyran-4-carboxylic acid; 4-Fluorooxane-4-carboxylic acid; 4-Fluorotetrahydro-2H-pyran-4-carboxylic acid CAS 1150617-62-1; 4-Fluoro-tetrahydropyran-4-carboxylic acid; 4-Fluorotetrahydropyran-4-carboxylic acid; 4-Fluorooxane-4-carboxylic acid; 4-Fluorotetrahydro-2H-pyran-4-carboxylic acid (9CI)
EINECS	Contact for details

Quality Control

Our production of 4-Fluorotetrahydro-2H-Pyran-4-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.