Description

4-Chloro-2-Fluoro-5-(Tbdmso)Phenylboronic Acid is a sophisticated organoboron building block, specifically a boronic acid derivative protected with a tert-butyldimethylsilyl (TBDMS) group on the sulfoxide moiety. This compound matters for its role as a key intermediate in modern cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the precise construction of complex biaryl and heteroaryl structures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the specific halogen pattern is required for bioactivity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester precursor for forming carbon-carbon bonds between aromatic rings, a cornerstone of modern medicinal chemistry.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and novel polymers with tailored properties.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating chemical probes for studying biological processes.
• Process Chemistry & Scale-up: Suitable for optimization and scaling from laboratory research to pilot plant and commercial manufacturing processes.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-(Tbdmso)Phenylboronic Acid
CAS No.	1150561-59-3
Molecular Formula	C12H17BClFO2SSi
Molecular Weight	318.69 g/mol
Synonyms	[4-Chloro-2-fluoro-5-[[(1,1-dimethylethyl)dimethylsilyl]sulfinyl]phenyl]boronic acid; (4-Chloro-2-fluoro-5-((tert-butyldimethylsilyl)sulfinyl)phenyl)boronic Acid; 4-Chloro-2-fluoro-5-((tert-butyldimethylsilyl)sulfinyl)benzeneboronic Acid; Boronic acid, B-[4-chloro-2-fluoro-5-[[(1,1-dimethylethyl)dimethylsilyl]sulfinyl]phenyl]-; 4-Chloro-2-Fluoro-5-(TBDMSO)Phenylboronic Acid; CAS 1150561-59-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-(Tbdmso)Phenylboronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications requiring research-grade to cGMP standards for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.