Description

2,4-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical synthesis. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecules containing a difluoromethoxyphenyl moiety.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro and methoxy substituents can modulate biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes used to study biological pathways and protein functions.

Basic Information

Product Name	2,4-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	1150561-57-1
Molecular Formula	C13H17BF2O3
Molecular Weight	270.09 g/mol
Synonyms	2,4-Difluoro-5-methoxyphenylboronic acid pinacol ester; 5-Methoxy-2,4-difluorophenylboronic acid pinacol ester; (2,4-Difluoro-5-methoxyphenyl)boronic acid pinacol ester; 2-(2,4-Difluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(2,4-Difluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1150561-57-1
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.