Description

5-Cyano-2-Fluoro-3-Methoxyphenylboronic Acid,Pinacol is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized aromatic boronic ester. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable coupling partners for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require complex aromatic scaffolds.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors for biochemical research and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	5-Cyano-2-Fluoro-3-Methoxyphenylboronic Acid,Pinacol
CAS No.	1150561-55-9
Molecular Formula	C14H17BFNO3
Molecular Weight	277.10 g/mol
Synonyms	5-Cyano-2-fluoro-3-methoxyphenylboronic acid pinacol ester; 2-Fluoro-3-methoxy-5-cyanophenylboronic acid pinacol ester; (5-Cyano-2-fluoro-3-methoxyphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(5-cyano-2-fluoro-3-methoxyphenyl)-1,3,2-dioxaborolane; Boronic acid, B-(5-cyano-2-fluoro-3-methoxyphenyl)-, 1,1-dimethylethyl ester; CAS 1150561-55-9
EINECS	Contact for details

Quality Control

Our production of 5-Cyano-2-Fluoro-3-Methoxyphenylboronic Acid,Pinacol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.