Description

2,2-Difluorocyclobutanecarboxylic Acid is a high-value, synthetically versatile fluorinated building block essential for advanced chemical synthesis. Its unique cyclobutane core with difluorination makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting protease inhibitors and other enzyme modulators.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the difluorocyclobutane moiety can improve compound activity and environmental profile.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and advanced materials with specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands and catalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the effects of fluorination in small molecules within academic and industrial R&D settings.
• Peptidomimetics: The carboxylic acid functionality and constrained ring system make it useful for designing and synthesizing peptide mimics in drug discovery.

Basic Information

Product Name	2,2-Difluorocyclobutanecarboxylic Acid
CAS No.	1150518-74-3
Molecular Formula	C5H6F2O2
Molecular Weight	136.10 g/mol
Synonyms	2,2-Difluorocyclobutanecarboxylic Acid; 2,2-Difluorocyclobutane-1-carboxylic Acid; Cyclobutanecarboxylic acid, 2,2-difluoro-; 1150518-74-3; 2,2-Difluoro-1-cyclobutanecarboxylic acid; Difluorocyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluorocyclobutanecarboxylic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.