Description

2-Fluoro-4,5-Dimethoxyphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex multi-step synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where specific fluorinated aromatic motifs are required for bioactivity.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, through controlled polymerization or functionalization.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes, leveraging the fluorine atom as a potential NMR or PET tracer.

Basic Information

Product Name	2-Fluoro-4,5-Dimethoxyphenylboronic Acid, Pinacol Ester
CAS No.	1150271-76-3
Molecular Formula	C14H20BFO4
Molecular Weight	282.12 g/mol
Synonyms	2-Fluoro-4,5-dimethoxyphenylboronic acid pinacol ester; 4,5-Dimethoxy-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-4,5-dimethoxybenzeneboronic acid pinacol ester; (2-Fluoro-4,5-dimethoxyphenyl)boronic acid pinacol ester; 2-Fluoro-4,5-dimethoxyphenyl-B(pin); 2-Fluoro-4,5-dimethoxyphenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1150271-76-3; BRN 15400643
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-4,5-Dimethoxyphenylboronic Acid, Pinacol Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity, assay, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.