Description

2-Acetamido-4-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound is a critical building block in modern organic synthesis, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorophenyl moiety is a desirable structural feature.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: An essential reagent in Suzuki-Miyaura cross-coupling reactions for forming carbon-carbon bonds between aromatic rings under mild conditions.
• Academic & R&D: Employed in university and corporate research laboratories for methodological development and exploring new chemical spaces.
• Bioconjugation & Probe Development: Potential use in creating bioconjugates or fluorescent probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-Acetamido-4-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1150271-67-2
Molecular Formula	C14H19BFNO3
Molecular Weight	279.12 g/mol
Synonyms	4-Fluoro-2-acetamidophenylboronic acid pinacol ester; 2-Acetamido-4-fluorobenzeneboronic acid pinacol ester; N-[4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 2-Acetamido-4-fluorophenyl-Bpin; (2-Acetamido-4-fluorophenyl)boronic acid pinacol ester; B-(2-Acetamido-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Acetamido-4-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.