Description

5-(T-Butyldimethylsiloxy)-2,3-Difluorophenylboronic is a high-value, organosilicon-protected boronic acid derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its primary value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides with enhanced efficacy.
• Material Science: Precursor for creating functionalized organic electronic materials and liquid crystals.
• Chemical Research: Versatile reagent in academic and industrial R&D for exploring new C-C bond formation methodologies.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	5-(T-Butyldimethylsiloxy)-2,3-Difluorophenylboronic
CAS No.	1150271-62-7
Molecular Formula	C12H19BF2O2Si
Molecular Weight	272.18 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-2,3-difluorophenylboronic acid; 2,3-Difluoro-5-[(tert-butyldimethylsilyl)oxy]benzeneboronic acid; 5-(Tert-Butyldimethylsiloxy)-2,3-Difluorobenzeneboronic Acid; 5-(TBDMSO)-2,3-Difluorophenylboronic Acid; [5-[(tert-Butyldimethylsilyl)oxy]-2,3-difluorophenyl]boronic acid; B-[5-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2,3-difluorophenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 5-(T-Butyldimethylsiloxy)-2,3-Difluorophenylboronic is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.