Description

Methyl3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Benzoate CAS NO 1150271-61-6 is a high-value, multifunctional chemical intermediate featuring both a boronic ester pinacol group and a trifluoromethyl-substituted aromatic ring. This compound is essential for advanced organic synthesis, particularly in cross-coupling reactions, due to its stability and reactivity profile. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials, such as ligands for OLEDs or charge-transport molecules.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and bioconjugation reagents targeting specific proteins or enzymes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a boronic ester handle onto a trifluoromethylated arene.
• Academic & Industrial R&D: Fundamental research tool in methodology development for new catalytic processes and C-C bond formation strategies.

Basic Information

Product Name	Methyl3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Benzoate
CAS No.	1150271-61-6
Molecular Formula	C15H18BF3O4
Molecular Weight	330.11 g/mol
Synonyms	Methyl 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzoate; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzoic Acid Methyl Ester; Methyl 3-Borono-5-(trifluoromethyl)benzoate, Pinacol Ester; 5-(Trifluoromethyl)isophthalic Acid 3-Methyl Ester 1-Pinacolboronate; [3-(Methoxycarbonyl)-5-(trifluoromethyl)phenyl]boronic Acid Pinacol Ester; Benzoic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Benzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize shelf life and prevent degradation of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.