Description

3-(Diethylcarbamoyl)-2-Fluorophenylboronic Acid, Pinacol Ester is a sophisticated organoboron building block, a pinacol-protected boronic ester, designed for advanced synthetic chemistry. This compound is critical for enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and agrochemical research. It is an essential reagent for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to construct complex fluorinated and functionalized aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems and amide functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated phenyl structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-handleable boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl compounds.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of structure-activity relationships (SAR) by introducing the diethylcarbamoyl-fluorophenyl moiety into candidate molecules.
• Ligand and Catalyst Development: Can be utilized as a precursor for creating specialized ligands or functionalized materials used in catalysis.
• Chemical Biology Probes: Employed in the synthesis of fluorinated molecular probes for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	3-(Diethylcarbamoyl)-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1150271-35-4
Molecular Formula	C17H25BFNO3
Molecular Weight	321.20 g/mol
Synonyms	2-Fluoro-3-(diethylcarbamoyl)phenylboronic acid pinacol ester; (3-(Diethylcarbamoyl)-2-fluorophenyl)boronic acid pinacol ester; 3-Diethylcarbamoyl-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-N,N-diethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; B-(3-[(Diethylamino)carbonyl]-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3-(Diethylcarbamoyl)-2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.