Description

4,5-Difluoro-2-Nitrophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both electron-withdrawing nitro and difluoro substituents, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials. We supply this intermediate with a focus on consistent high purity and reliable global availability to support your most demanding projects.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoro and nitro groups contribute to biological activity and stability.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and inhibitors that target specific enzymes or biological pathways.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis research.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for the production of bespoke compounds and libraries for client projects.

Basic Information

Product Name	4,5-Difluoro-2-Nitrophenylboronic Acid
CAS No.	1150114-59-2
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	(4,5-Difluoro-2-nitrophenyl)boronic acid; 2-Nitro-4,5-difluorobenzeneboronic acid; 4,5-Difluoro-2-nitrobenzeneboronic acid; B-(4,5-Difluoro-2-nitrophenyl)boronic acid; 1150114-59-2; 4,5-Difluoro-2-nitrophenyl-B(OH)2; 2-Nitro-4,5-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4,5-Difluoro-2-Nitrophenylboronic Acid is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and our quality control protocols include comprehensive analytical characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.