Description

2-(Benzyloxy)-3,5-Difluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing complex difluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a versatile boronic acid reagent for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in lead optimization, structure-activity relationship (SAR) studies, and route scouting.
• Ligand Synthesis: Can be utilized in the preparation of specialized ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	2-(Benzyloxy)-3,5-Difluorophenylboronic Acid
CAS No.	1150114-56-9
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	2-(Benzyloxy)-3,5-Difluorobenzeneboronic Acid; (2-(Benzyloxy)-3,5-Difluorophenyl)boronic Acid; 3,5-Difluoro-2-(phenylmethoxy)benzeneboronic Acid; B-[2-(Benzyloxy)-3,5-difluorophenyl]boronic Acid; 1150114-56-9; AKOS015903991; FT-0658089; SCHEMBL15506227; A829217
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-3,5-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.