Description

5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid is a high-value, organoboron building block featuring both a protected phenol and a fluorine substituent. This compound is critical for modern synthetic chemistry, enabling precise Suzuki-Miyaura cross-coupling reactions to construct complex biaryl and heterobiaryl structures. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates and active ingredients, where its unique substitution pattern allows for strategic functionalization and diversification of molecular scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing fluorinated biaryl motifs found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic architectures.
• Material Science Research: Serves as a monomer or precursor for creating advanced polymers and organic electronic materials with tailored properties.
• Ligand and Catalyst Preparation: Employed in the development of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Facilitates the synthesis of fluorinated molecular probes and tags for studying biological systems and mechanisms.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring this specific boronic acid derivative.

Basic Information

Product Name	5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid
CAS No.	1150114-53-6
Molecular Formula	C12H20BFO3Si
Molecular Weight	270.18 g/mol
Synonyms	[2-Fluoro-5-[(1,1-dimethylethyl)dimethylsilyl]oxy]phenylboronic Acid; 2-Fluoro-5-[(tert-Butyldimethylsilyl)oxy]benzeneboronic Acid; 5-(tert-Butyldimethylsiloxy)-2-fluorophenylboronic Acid; 2-Fluoro-5-(TBDMS-oxy)phenylboronic Acid; (2-Fluoro-5-((tert-butyldimethylsilyl)oxy)phenyl)boronic Acid; Boronic acid, B-[2-fluoro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-; 5-(Tert-Butyldimethylsilyloxy)-2-fluorobenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.