Description

(1R,2R)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine, Min. 97% is a high-purity, chiral bisphosphine-diamine hybrid ligand, a critical component in asymmetric catalysis. This compound matters because it enables highly selective and efficient transition metal-catalyzed reactions, which are essential for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. Industrial researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical sectors need this ligand to develop and scale up sustainable, cost-effective synthetic routes for complex chiral molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic production of enantiomerically pure active pharmaceutical ingredients (APIs) and key chiral building blocks.
• Fine Chemical Manufacturing: Enables the synthesis of high-value, complex chiral molecules for agrochemicals, flavors, and fragrances.
• Catalyst Development & Screening: Serves as a privileged ligand structure in R&D for discovering new asymmetric transformations.
• Cross-Coupling Reactions: Can be employed in asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions.
• Academic & Industrial Research: A valuable tool for methodological studies in organic synthesis and catalysis.

Basic Information

Product Name	(1R,2R)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine, Min. 97%
CAS No.	1150113-65-7
Molecular Formula	C52H56N2P2
Molecular Weight	770.96 g/mol
Synonyms	(1R,2R)-Cyclohexane-1,2-diamine, N,N-bis[2-(di-p-tolylphosphino)benzyl]-; (R,R)-DACH-Phenyl Trost Ligand Derivative; (1R,2R)-N,N-Bis[2-(Di-p-tolylphosphino)benzyl]-1,2-cyclohexanediamine; (R,R)-Benzyl-DACH-PTOL; Chiral Diphosphine-Diamine Ligand; Trost Ligand Analog; Josiphos-type Hybrid Ligand; (R,R)-Benzyl-DACH-(p-Tolyl)2P
EINECS	Contact for details

Quality Control

Our production of (1R,2R)-N,n-Bis[2-(Di-p-Tolylphosphino)Benzyl]Cyclohexane-1,2-Diamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot is characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; minimize exposure to air and ambient light during handling and weighing.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (Chiral HPLC)	Min. 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.