Description

1-(3-Bromo-5-Fluorophenyl)-2-Methylpropan-1-One is a high-purity fluorinated and brominated aromatic ketone building block. This compound is valued for its unique halogenated structure, which provides versatile reactivity for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Serves as a crucial building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic core.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and pharmacological studies.
• Cross-Coupling Reactions: The bromo and fluoro substituents make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-purity halogenated intermediates.

Basic Information

Product Name	1-(3-Bromo-5-Fluorophenyl)-2-Methylpropan-1-One
CAS No.	1147871-74-6
Molecular Formula	C10H10BrFO
Molecular Weight	245.09 g/mol
Synonyms	3'-Bromo-5'-fluoro-2-methylpropiophenone; 2-Methyl-1-(3-bromo-5-fluorophenyl)propan-1-one; 1-(3-Bromo-5-fluorophenyl)-2-methyl-1-propanone; 3-Bromo-5-fluoro-α,α-dimethylacetophenone; α,α-Dimethyl-3-bromo-5-fluoroacetophenone; Propiophenone, 3'-bromo-5'-fluoro-2-methyl-; 1-(3-Bromo-5-fluorophenyl)-2-methylpropan-1-one
EINECS	Contact for details

Quality Control

Our 1-(3-Bromo-5-Fluorophenyl)-2-Methylpropan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.