Description

3-Bromo-n-Cyclopropyl-5-Fluorobenzamide is a high-purity, advanced pharmaceutical intermediate featuring a unique halogenated benzamide structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system and metabolic disorders. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those requiring a halogenated, cyclopropyl-substituted benzamide scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to modulate the potency, selectivity, and pharmacokinetic properties of potential drug molecules.
• API Synthesis: Serves as a precursor in multi-step synthetic routes for the production of complex target molecules in preclinical and clinical development.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information

Product Name	3-Bromo-n-Cyclopropyl-5-Fluorobenzamide
CAS No.	1147712-88-6
Molecular Formula	C10H9BrFNO
Molecular Weight	258.09 g/mol
Synonyms	3-Bromo-N-cyclopropyl-5-fluorobenzamide; 5-Fluoro-3-bromo-N-cyclopropylbenzamide; Benzamide, 3-bromo-N-cyclopropyl-5-fluoro-; 1147712-88-6; 3-Br-N-cyclopropyl-5-F-benzamide
EINECS	Contact for details

Quality Control

Our 3-Bromo-n-Cyclopropyl-5-Fluorobenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.