Description

Safinamide-D4 CAS NO 1147299-69-1 is a deuterated analog of the active pharmaceutical ingredient Safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor. This high-purity stable isotope-labeled compound is an essential reference standard and internal standard for quantitative analysis in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and academic institutions for applications in bioanalytical method development, pharmacokinetic studies, and drug metabolism research.

Application

• Bioanalytical Method Development: Serves as a critical internal standard for the accurate quantification of Safinamide in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Metabolite Identification: Used as a tracer to study metabolic pathways and identify metabolites, aiding in the assessment of drug safety and efficacy.
• Quality Control and Impurity Profiling: Acts as a reference standard to ensure the purity and identity of Safinamide in active pharmaceutical ingredient (API) and finished drug product batches.
• Doping Control Analysis: Potential application in sports anti-doping laboratories for the detection and confirmation of Safinamide.
• Forensic Toxicology: Used as a calibrant or standard in forensic investigations for the precise identification and quantification of the substance.

Basic Information

Product Name	Safinamide-D4
CAS No.	1147299-69-1
Molecular Formula	C17H15D4F3N2O2
Molecular Weight	344.35 g/mol
Synonyms	2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methyl]-N2-propan-2-ylaminoacetamide-D4; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide-D4; FCE 26743-D4; PNU-151774E-D4; Deuterated Safinamide; Safinamide (tetradeuterated); Safinamide-d4
EINECS	Contact for details

Quality Control

Our Safinamide-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural identity. Standard testing includes HPLC for chemical purity, NMR and/or MS for structural confirmation and isotopic purity assessment. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support compliance with cGMP and ISO guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.