Description

4-Amino-n-((2R,3S)-3-Amino-2-Hydroxy-4-Phenylbutyl)-n-(Isobutyl-D9)Benzenesulfonamide is a high-purity, deuterated sulfonamide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and reference standard for the synthesis and analysis of deuterated drug candidates, offering enhanced metabolic stability for pharmacokinetic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research-scale synthesis of deuterated active pharmaceutical ingredients (APIs), particularly protease inhibitors.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and analyze the metabolic pathways of lead compounds.
• Reference Standard: Serves as an analytical standard for quality control and method validation in HPLC, LC-MS, and NMR analyses of complex drug substances.
• Isotope Labeling Research: Employed in mechanistic studies to investigate reaction pathways and biological interactions using deuterium as a stable isotopic label.
• Preclinical Research: Utilized in the development and optimization of new chemical entities (NCEs) targeting viral and other enzymatic pathways.

Basic Information

Product Name	4-Amino-n-((2R,3S)-3-Amino-2-Hydroxy-4-Phenylbutyl)-n-(Isobutyl-D9)Benzenesulfonamide
CAS No.	1146967-60-3
Molecular Formula	C20H19D9N3O3S
Molecular Weight	405.60 g/mol
Synonyms	N-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-4-amino-N-(2-methylpropyl-d9)benzenesulfonamide; (2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl-(4-aminophenyl)sulfonyl-(isobutyl-d9)amine; Deuterated Amprenavir Intermediate; D9-Isobutyl Amprenavir Sulfonamide Analog; 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-(isobutyl-d9)benzenesulfonamide; (R,S)-Amino Hydroxy Phenylbutyl D9-sulfonamide; Benzenesulfonamide, 4-amino-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(2-methylpropyl-d9)amino]propyl]-
EINECS	Contact for details

Quality Control

Our 4-Amino-n-((2R,3S)-3-Amino-2-Hydroxy-4-Phenylbutyl)-n-(Isobutyl-D9)Benzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, isotopic enrichment analysis, and impurity profiling to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing specifications for assay, chiral purity, deuterium enrichment, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.