Description

Pentanamide, 2-Amino-5,5,5-Trifluoro-,(2R)- is a high-purity, non-natural chiral amino acid derivative featuring a trifluoromethyl group, which imparts unique physicochemical properties. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of advanced intermediates and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide analogs and protease inhibitors.
• Agrochemical Research: Used in developing novel herbicides and pesticides with improved efficacy and environmental profiles.
• Peptidomimetics: Serves as a constrained, fluorinated amino acid residue in the design of peptide mimetics for drug discovery.
• Chemical Biology Probes: Incorporated into probes to study enzyme mechanisms and protein-protein interactions due to the fluorine label.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective catalytic reactions.
• Material Science: Potential monomer for specialty polymers with unique surface properties.

Basic Information

Product Name	Pentanamide, 2-Amino-5,5,5-Trifluoro-,(2R)-
CAS No.	1146852-37-0
Molecular Formula	C5H7F3N2O
Molecular Weight	168.12 g/mol
Synonyms	(R)-2-Amino-5,5,5-trifluoropentanamide; (2R)-2-Amino-5,5,5-trifluoropentanamide; D-2-Amino-5,5,5-trifluorovaleramide; (R)-5,5,5-Trifluoronorvalinamide; 2-Amino-5,5,5-trifluoro-(R)-pentanamide; (R)-α-Amino-β,β,β-trifluorobutyramide (deprecated structure-based); 1146852-37-0; (2R)-2-Azanyl-5,5,5-trifluoro-pentanamide
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-5,5,5-trifluoropentanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chiral excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.