Description

Pentanamide, 2-[[(4-Chlorophenyl)Sulfonyl]Amino]-5,5,5-Trifluoro-, (2R)- is a high-purity, single-enantiomer chiral building block featuring a trifluoromethyl group and a sulfonamide linkage. This compound is of significant value in advanced pharmaceutical research and development, particularly for creating novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding selectivity. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the trifluoromethyl group and specific stereochemistry contribute to biological activity.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function and protein-protein interactions.
• Material Science Research: Potential precursor for specialty polymers or coatings where fluorine incorporation is desired for specific properties like chemical resistance or low surface energy.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex organic molecules.

Basic Information

Product Name	Pentanamide, 2-[[(4-Chlorophenyl)Sulfonyl]Amino]-5,5,5-Trifluoro-, (2R)-
CAS No.	1146699-67-3
Molecular Formula	C11H10ClF3N2O3S
Molecular Weight	342.72 g/mol
Synonyms	(2R)-2-[[(4-Chlorophenyl)sulfonyl]amino]-5,5,5-trifluoropentanamide; (R)-2-((4-Chlorophenyl)sulfonamido)-5,5,5-trifluoropentanamide; 2-[[(4-Chlorophenyl)sulfonyl]amino]-5,5,5-trifluoropentanamide, (2R)-; UNII-9V5G2C8R4F; 9V5G2C8R4F; SCHEMBL21824027; DTXSID60635660; AKOS040759623
EINECS	Contact for details

Quality Control

Our Pentanamide, 2-[[(4-Chlorophenyl)Sulfonyl]Amino]-5,5,5-Trifluoro-, (2R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.