Description

(2R)-2-Amino-5,5,5-trifluoro-pentanamide hydrochloride is a high-purity, non-natural amino acid derivative characterized by its chiral center and trifluoromethyl group. This compound matters as a versatile and valuable chiral building block for pharmaceutical research and development, offering unique steric and electronic properties. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where fluorine substitution is desired to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially protease inhibitors and enzyme modulators.
• Peptidomimetics: Incorporation into peptide analogs to enhance metabolic stability, membrane permeability, and receptor selectivity.
• Agrochemical Research: Used in the synthesis of advanced, fluorine-containing active ingredients for crop protection.
• Chemical Biology Probes: Serves as a building block for labeled compounds and activity-based probes to study enzyme function.
• Ligand Synthesis: Useful for creating chiral ligands for asymmetric catalysis and metal complexation.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research in organic and medicinal chemistry.

Basic Information

Product Name	(2R)-2-Amino-5,5,5-trifluoro-pentanamide hydrochloride
CAS No.	1146699-58-2
Molecular Formula	C6H10F3N2O • HCl
Molecular Weight	224.61 g/mol
Synonyms	(R)-2-Amino-5,5,5-trifluoro-pentanamide hydrochloride; D-2-Amino-5,5,5-trifluoro-valeramide hydrochloride; (2R)-2-Amino-5,5,5-trifluoro-valeramide HCl; 2-Amino-5,5,5-trifluoro-pentanamide hydrochloride, (2R)-; 1146699-58-2; (R)-5,5,5-Trifluoronorvalinamide hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-5,5,5-trifluoro-pentanamide hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.