Description

4-(Ethoxycarbonylmethyl)-3-Fluorophenylboronic Acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in its dual functional groups, enabling it to act as a versatile coupling partner in cross-coupling reactions, such as the Suzuki-Miyaura reaction, for constructing complex fluorinated aromatic systems. This high-purity intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Employed in the development of organic electronic materials, including OLEDs and semiconductors, where fluorinated aromatic units are desirable.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid partner for forming carbon-carbon bonds between aromatic rings under mild conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated molecular probes for studying biological processes.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Ethoxycarbonylmethyl)-3-Fluorophenylboronic Acid
CAS No.	1146614-44-9
Molecular Formula	C10H12BFO4
Molecular Weight	225.81 g/mol
Synonyms	[3-Fluoro-4-(2-ethoxy-2-oxoethyl)phenyl]boronic acid; 4-(2-Ethoxy-2-oxoethyl)-3-fluorobenzeneboronic acid; 3-Fluoro-4-(ethoxycarbonylmethyl)benzeneboronic acid; (3-Fluoro-4-(2-ethoxy-2-oxoethyl)phenyl)boronic acid; Boronic acid, B-[3-fluoro-4-[(ethoxycarbonyl)methyl]phenyl]-; 4-Carbethoxymethyl-3-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 4-(Ethoxycarbonylmethyl)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot upon request, supporting your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.