Description

3-Fluoro-5-(Hydroxymethyl)Phenylboronic Acid is a high-purity, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions and a hydroxymethyl substituent that offers a versatile handle for further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Incorporated into the backbone of organic electronic materials, such as OLEDs and OFETs, due to its conjugated aromatic system and functional handles.
• Bioconjugation and Probe Synthesis: The hydroxymethyl group facilitates attachment to biomolecules, making it useful for creating fluorescent probes, sensors, and antibody-drug conjugates (ADCs).
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic pathways and constructing complex, fluorinated aromatic scaffolds.

Basic Information

Product Name	3-Fluoro-5-(Hydroxymethyl)Phenylboronic Acid
CAS No.	1146614-40-5
Molecular Formula	C7H8BFO3
Molecular Weight	169.95 g/mol
Synonyms	(3-Fluoro-5-(hydroxymethyl)phenyl)boronic acid; 3-Fluoro-5-(hydroxymethyl)benzeneboronic acid; 5-(Hydroxymethyl)-3-fluorophenylboronic acid; (5-(Hydroxymethyl)-3-fluorophenyl)boronic acid; 3-Fluoro-5-hydroxymethylphenylboronic acid; B-(3-Fluoro-5-(hydroxymethyl)phenyl)boronic acid; 1146614-40-5; 3-Fluoro-5-methylolphenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of our 3-Fluoro-5-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing. We ensure compliance with the high-purity standards required for pharmaceutical and advanced chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.