Description

Mal-Peg2-Oxyamine is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group for thiol conjugation and an oxyamine group for carbonyl (aldehyde/ketone) ligation. This compound is essential for creating stable, site-specific bioconjugates, enabling the precise cross-linking of biomolecules under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced diagnostics, facilitating the production of antibody-drug conjugates (ADCs), peptide-PEG conjugates, and sensor surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• PEGylation of Peptides/Proteins: Introduction of a hydrophilic PEG spacer to improve pharmacokinetic properties and stability of therapeutic biomolecules.
• Surface Functionalization: Immobilization of proteins, antibodies, or other ligands onto biosensor chips, microarrays, or nanoparticles for diagnostic applications.
• Cross-linking Reagent: For studying protein-protein interactions or creating defined protein complexes in structural biology.
• Biomolecule Labeling: Attaching fluorescent dyes, tags, or other probes to specific sites on proteins or oligonucleotides for tracking and detection.
• Hydrogel Formation: As a cross-linking agent in the synthesis of biocompatible hydrogels for drug delivery or tissue engineering.

Basic Information

Product Name	Mal-Peg2-Oxyamine
CAS No.	1146245-73-9
Molecular Formula	C15H24N2O7
Molecular Weight	344.36 g/mol
Synonyms	Maleimide-PEG2-oxyamine; 3-[2-[2-(Aminooxy)ethoxy]ethoxy]-1H-pyrrole-2,5-dione; Mal-PEG2-ONH2; Maleimide-PEG2-aminooxy; O-(2-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethyl)hydroxylamine; 1-(8-Aminooxy-3,6-dioxaoctyl)maleimide; Heterobifunctional PEG linker, Maleimide and Oxyamine
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Oxyamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Identification (Mass Spec)	Conforms (M+H+ or M+Na+)
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.