Description

2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound matters as a critical building block in modern cross-coupling reactions, enabling the efficient synthesis of complex, functionalized aromatic structures. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing trifluoromethyl and chloro-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the specific halogenated, fluorinated aromatic moiety imparts desired biological activity and stability.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs or semiconductors, where precise control over aromatic structure is required.
• Chemical Biology Probes: Utilized to construct molecular probes and tags for studying biological systems, leveraging the stability of the pinacol boronate ester group.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1146214-95-0
Molecular Formula	C₁₃H₁₅BClF₃O₂
Molecular Weight	306.52 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)benzeneboronic acid pinacol ester; [2-Chloro-5-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-Chloro-α,α,α-trifluoro-p-tolylboronic acid pinacol ester; (2-Chloro-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4-Chloro-α,α,α-trifluoro-m-tolylboronic acid pinacol ester; Pinacol [2-Chloro-5-(trifluoromethyl)phenyl]boronate; 2-Chloro-5-trifluoromethylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.