Description

1-(Iodomethyl)-4-(Trifluoromethoxy)Benzene is a high-value, multi-functional aromatic building block containing both an iodomethyl and a trifluoromethoxy substituent. This compound is critical for introducing the versatile benzyl iodide moiety and the metabolically stable, lipophilic trifluoromethoxy group into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating candidates with enhanced metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group can improve biological activity and environmental persistence profiles.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis, such as palladium-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the creation of functionalized monomers or additives for advanced polymers and liquid crystals, leveraging its unique electronic properties.
• Radiochemistry: Potential precursor for iodine-123 or iodine-131 labeled compounds used in medical imaging (SPECT) and radiotherapy, due to the reactive iodomethyl group.
• Chemical Biology: Useful for bioconjugation and probe development, where the iodine can be displaced in nucleophilic substitution reactions to attach fluorescent tags or other reporter groups.

Basic Information

Product Name	1-(Iodomethyl)-4-(Trifluoromethoxy)Benzene
CAS No.	1145780-74-0
Molecular Formula	C9H8F3IO
Molecular Weight	316.06 g/mol
Synonyms	α-Iodo-4-(trifluoromethoxy)toluene; 4-(Trifluoromethoxy)benzyl Iodide; (4-(Trifluoromethoxy)phenyl)methyl Iodide; 1-Iodomethyl-4-trifluoromethoxybenzene; p-(Trifluoromethoxy)benzyl Iodide; Benzene, 1-(iodomethyl)-4-(trifluoromethoxy)-; Iodomethyl Trifluoromethoxy Benzene
EINECS	Contact for details

Quality Control

Our 1-(Iodomethyl)-4-(Trifluoromethoxy)Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom purity grades or analytical packages are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to the light-sensitive and potentially moisture-sensitive nature of iodinated compounds, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.