Description

(2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in modern organic synthesis. This compound matters for its critical role in constructing complex molecules with defined stereochemistry, enabling the development of novel pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of peptide-based drugs, enzyme inhibitors, and other advanced therapeutic agents where precise spatial orientation is essential for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery.
• Peptide Chemistry: Used to incorporate the fluorinated proline analog into peptide chains to study and modulate peptide conformation, stability, and biological activity.
• Medicinal Chemistry Research: Serves as a building block in structure-activity relationship (SAR) studies to explore the impact of fluorination on drug potency, selectivity, and metabolic stability.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for investigating enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct other enantiomerically pure compounds.

Basic Information

Product Name	(2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid Hydrochloride
CAS No.	1143504-73-7
Molecular Formula	C5H9FNO2·HCl
Molecular Weight	169.59 (Free base) / 206.05 (Hydrochloride)
Synonyms	(2R,4S)-4-Fluoroproline Hydrochloride; (2R,4S)-4-Fluoro-L-proline HCl; 4-Fluoro-(2R,4S)-proline hydrochloride; 4-Fluoro-D-proline (trans) hydrochloride; (2R,4S)-4-Fluoropyrrolidine-2-carboxylic acid hydrochloride; trans-4-Fluoro-L-proline hydrochloride; L-4-Fluoroproline hydrochloride (trans); 4-Fluoro-L-proline hydrochloride (2R,4S)
EINECS	Contact for details

Quality Control

Our (2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.