Description

Etravirine D4 is a deuterated isotopologue of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Etravirine, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for the precise quantification and pharmacokinetic studies of Etravirine in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and bioanalytical method development.

Application

• Bioanalytical Reference Standard: Serves as a critical internal standard for the accurate quantification of Etravirine in plasma, serum, and other biological samples via mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the parent drug without interference from metabolites.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) and pharmacokinetic profiling in clinical trials for HIV treatment regimens.
• Method Development and Validation: Essential for developing, validating, and ensuring the reproducibility and reliability of LC-MS/MS analytical methods in compliance with GLP guidelines.
• Impurity Profiling and Characterization: Aids in the identification and characterization of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Etravirine D4
CAS No.	1142095-93-9
Molecular Formula	C20H11D4BrN6O
Molecular Weight	447.31 g/mol
Synonyms	4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d4; TMC125-d4; Intelence-d4; (4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl]oxy]-3,5-dimethylbenzonitrile)-d4; Deuterated Etravirine; Etravirine (tetradeuterated)
EINECS	Contact for details

Quality Control

Our Etravirine D4 is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and residual solvents. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.