Description

5-Fluoro-6-Hydroxypyridin-3-Ylboronic Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in its role as a versatile building block for the Suzuki-Miyaura cross-coupling reaction, a cornerstone method for forming carbon-carbon bonds. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing complex heterocyclic scaffolds. Its unique substitution pattern makes it essential for creating novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated pyridine-boronic acid structure.
• Chemical Biology & Proteomics: Serves as a key reagent for bioconjugation and the development of molecular probes and sensors.
• Academic & Contract Research: A fundamental reagent for methodological development in cross-coupling chemistry and heterocycle synthesis within R&D laboratories.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	5-Fluoro-6-Hydroxypyridin-3-Ylboronic Acid
CAS No.	1141886-36-3
Molecular Formula	C5H5BFNO3
Molecular Weight	156.91 g/mol
Synonyms	(5-Fluoro-6-hydroxy-3-pyridinyl)boronic acid; 5-Fluoro-6-hydroxy-3-pyridineboronic acid; 3-Borono-5-fluoro-6-hydroxypyridine; 5-Fluoro-6-hydroxypyridine-3-boronic acid; 1141886-36-3; 5-Fluoro-6-hydroxy-3-pyridylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Hydroxypyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.