Description

1,3-Difluoro-2-Iodo-5-Methoxybenzene is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique reactivity profile, where the iodine atom serves as an excellent site for further functionalization via cross-coupling reactions, while the fluorine and methoxy groups modulate electronic properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery programs, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for liquid crystals, organic semiconductors, and advanced polymers requiring specific electronic characteristics.
• Cross-Coupling Reactions: The iodine moiety is ideal for Suzuki, Stille, and Sonogashira couplings to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: Used in studies exploring the effects of fluorine substitution on molecular properties like metabolic stability and lipophilicity.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring tailored halogenated intermediates.

Basic Information

Product Name	1,3-Difluoro-2-Iodo-5-Methoxybenzene
CAS No.	1140622-69-0
Molecular Formula	C7H5F2IO
Molecular Weight	285.02 g/mol
Synonyms	2-Iodo-1,3-difluoro-5-methoxybenzene; 5-Methoxy-1,3-difluoro-2-iodobenzene; 1,3-Difluoro-5-methoxy-2-iodobenzene; Benzene, 1,3-difluoro-2-iodo-5-methoxy-; 1140622-69-0; DFIMB
EINECS	Contact for details

Quality Control

Every batch of 1,3-Difluoro-2-Iodo-5-Methoxybenzene is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistent purity and identity, critical for reproducible research and scale-up. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.