Description

5-Methoxy-4-(Trimethylsilyl)Nicotinonitrile is a specialized organosilicon-substituted pyridine derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of a methoxy group and a trimethylsilyl-protected nitrile moiety, which enables precise functionalization and scaffold diversification. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic frameworks and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for nicotinic acid derivatives and other nitrogen-containing heterocycles with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the pyridine core is a common structural motif.
• Material Science Precursor: Serves as a starting material for creating functionalized organic molecules used in organic electronics or as ligands in catalytic systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, exploring new C-H functionalization or cross-coupling reactions facilitated by the silyl group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API batches for clinical trials.

Basic Information

Product Name	5-Methoxy-4-(Trimethylsilyl)Nicotinonitrile
CAS No.	1138444-11-7
Molecular Formula	C10H14N2OSi
Molecular Weight	206.32 g/mol
Synonyms	4-(Trimethylsilyl)-5-methoxypyridine-3-carbonitrile; 5-Methoxy-4-(trimethylsilyl)-3-pyridinecarbonitrile; 3-Cyano-5-methoxy-4-(trimethylsilyl)pyridine; Nicotinonitrile, 5-methoxy-4-(trimethylsilyl)-; 5-Methoxy-4-trimethylsilylnicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-Methoxy-4-(Trimethylsilyl)Nicotinonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR (1H, 13C) and IR for structural confirmation, and GC-MS for impurity profiling. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.