Description

α-Maleimidopropionyl-ω-Succinimidyl-10(Ethylene Glycol) is a heterobifunctional, amine- and sulfhydryl-reactive crosslinker featuring a hydrophilic polyethylene glycol (PEG) spacer. This compound is engineered for the stable, site-specific conjugation of biomolecules, such as antibodies, proteins, and peptides, under mild aqueous conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, diagnostic assay development, and ADC (Antibody-Drug Conjugate) payload linking.

Application

• Antibody-Drug Conjugate (ADC) Linker: For connecting cytotoxic payloads to monoclonal antibodies via stable thioether bonds.
• Protein/Peptide Labeling: Site-specific attachment of fluorophores, enzymes, or other probes to cysteine residues.
• Surface Functionalization: Immobilization of proteins or peptides onto maleimide-activated surfaces, beads, or biosensors.
• Polymer-Protein Conjugates: Creating PEGylated therapeutics to improve pharmacokinetics and reduce immunogenicity.
• Diagnostic Reagent Development: Conjugation of detection enzymes or tags to antibodies for ELISA and lateral flow assays.
• Biomaterial Crosslinking: Modification of hydrogels or other biomaterials to incorporate bioactive peptides.

Basic Information

Product Name	α-Maleimidopropionyl-ω-Succinimidyl-10(Ethylene Glycol)
CAS No.	1137109-22-8
Molecular Formula	C33H51N3O16
Molecular Weight	745.77 g/mol
Synonyms	Maleimide-PEG10-NHS ester; NHS-PEG10-Maleimide; MAL-PEG10-NHS; SM(PEG)10; Succinimidyl-[(N-maleimidopropionamido)-decaeethyleneglycol] ester; 3-Maleimidopropionic acid N-hydroxysuccinimide ester PEG10; N-(3-Maleimidopropionyloxy)succinimide-PEG10; Heterobifunctional PEG crosslinker, NHS-PEG-MAL
EINECS	Contact for details

Quality Control

Our α-Maleimidopropionyl-ω-Succinimidyl-10(Ethylene Glycol) is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. Under these conditions, the product is typically stable for 24 months from the date of receipt. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage under inert atmosphere, consult the technical data sheet.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Substitution	≥ 90% (NHS ester, Maleimide)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.