Description

Amino-(3,4-Difluoro-Phenyl)-Acetic Acid Hcl CAS NO 1136835-65-8 is a high-purity, fluorinated aromatic amino acid derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the precise introduction of a difluorophenyl moiety and a functionalized acetic acid backbone, enabling the development of novel compounds with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and sophisticated crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluorophenyl group enhances biological activity and environmental stability.
• Peptide Mimetics & Modifications: Incorporation into peptide chains to create analogs with improved metabolic stability, bioavailability, and target binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials requiring fluorinated aromatic components.
• Chemical Biology Probes: Useful for labeling and probing biological systems due to its reactive amino and carboxylic acid functional groups.

Basic Information

Product Name	Amino-(3,4-Difluoro-Phenyl)-Acetic Acid Hcl
CAS No.	1136835-65-8
Molecular Formula	C8H8F2NO2·HCl
Molecular Weight	223.61 (Free base) / 260.07 (HCl salt)
Synonyms	2-Amino-2-(3,4-difluorophenyl)acetic acid hydrochloride; (3,4-Difluorophenyl)glycine hydrochloride; DL-3,4-Difluorophenylglycine HCl; Amino(3,4-difluorophenyl)ethanoic acid hydrochloride; 2-(3,4-Difluorophenyl)glycine HCl; NSC 1136835-65-8; (RS)-2-Amino-2-(3,4-difluorophenyl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Amino-(3,4-Difluoro-Phenyl)-Acetic Acid Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (or as specified)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.