Description

Ethyl-β-D-Glucuronide-D5 is a stable isotope-labeled internal standard, specifically deuterated at five positions, which is critical for achieving high accuracy and precision in quantitative analytical methods. This compound is essential for researchers and laboratories requiring definitive quantification of ethyl glucuronide (EtG), a direct biomarker for ethanol consumption, in complex biological matrices. It is primarily used by forensic toxicology laboratories, clinical research facilities, and pharmaceutical companies engaged in substance abuse testing, pharmacokinetic studies, and method development and validation.

Application

• Quantitative Internal Standard for LC-MS/MS: Serves as the critical reference compound for the accurate quantification of ethyl glucuronide (EtG) in urine, blood, serum, and hair samples using liquid chromatography-tandem mass spectrometry.
• Forensic Toxicology and Workplace Testing: Enables reliable and legally defensible testing for recent alcohol consumption in forensic investigations, workplace drug and alcohol screening programs, and driving under the influence (DUI) cases.
• Clinical Research and Diagnostics: Used in studies investigating alcohol metabolism, alcoholism treatment monitoring, liver function assessment, and the correlation between EtG levels and alcohol intake.
• Pharmaceutical Method Development: Employed in the development and validation of robust bioanalytical methods for drug interaction studies where alcohol consumption is a co-factor.
• Reference Material for Calibration: Acts as a high-purity calibrant for establishing standard curves, ensuring method linearity and reproducibility across different analytical batches and instruments.
• Quality Control in Diagnostic Kits: Incorporated into commercial and in-house diagnostic test kits as a built-in quality control measure to verify assay performance and correct for sample preparation variability.

Basic Information

Product Name	Ethyl-β-D-Glucuronide-D5
CAS No.	1135070-98-2
Molecular Formula	C8H8D5O7
Molecular Weight	217.20 g/mol (for deuterated form)
Synonyms	Ethyl β-D-Glucopyranosiduronic Acid-d5; EtG-d5; Ethyl Glucuronide-d5; 1-O-Ethyl-β-D-glucopyranuronic Acid-d5; Ethyl-D5-β-D-Glucuronide; Deuterated Ethyl Glucuronide (5 positions); 2,3,4,5,6-Pentadeuteroethyl β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Ethyl-β-D-Glucuronide-D5 is manufactured under strict quality-controlled conditions to ensure the high chemical and isotopic purity required for sensitive mass spectrometry applications. Each batch undergoes comprehensive analysis, including HPLC for chemical purity and MS/MS for isotopic enrichment verification. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic abundance, and solvent content. Our quality system is designed to support GMP/GLP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.