Description

Boc-D-Threo-3-(Thiophen-2-Yl)Serine CAS NO 1134940-20-7 is a high-purity, non-natural amino acid derivative featuring a thiophene side chain and Boc (tert-butoxycarbonyl) protecting group on the amine. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a unique, sulfur-containing amino acid analog into peptide sequences.
• Chemical Biology & Proteomics: Serves as a tool compound for studying protein-protein interactions and designing activity-based probes.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing the thiophene moiety, which can influence lipophilicity and binding affinity.
• Process Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	Boc-D-Threo-3-(Thiophen-2-Yl)Serine
CAS No.	1134940-20-7
Molecular Formula	C₁₂H₁₇NO₅S
Molecular Weight	287.33 g/mol
Synonyms	(2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-3-(thiophen-2-yl)propanoic acid; D-Threo-3-(2-Thienyl)serine, N-Boc-; Boc-D-3-(2-Thienyl)serine; tert-Butyl ((2R,3S)-3-hydroxy-1-oxo-1-(thiophen-2-yl)propan-2-yl)carbamate; N-Boc-D-threo-3-(2-thienyl)serine; N-(tert-Butoxycarbonyl)-D-threo-3-(2-thienyl)serine; Boc-D-Thr(2-Thi)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Threo-3-(Thiophen-2-Yl)Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.