Description

Zoledronic-D3 Acid CAS NO 1134798-26-7 is a deuterated analog of zoledronic acid, a potent bisphosphonate, where specific hydrogen atoms are replaced with deuterium. This isotopic labeling is crucial for advanced pharmacokinetic and metabolic studies, providing enhanced analytical precision and stability. It is an essential reference standard and intermediate for pharmaceutical R&D teams in the development and quality control of next-generation osteoporosis and bone metastasis treatments.

Application

• Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalytical methods for quantifying zoledronic acid in biological matrices.
• Critical metabolic tracer in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of bisphosphonate therapies.
• Key high-purity intermediate in the synthesis of novel deuterated drug candidates aimed at improving metabolic stability and therapeutic profiles.
• Essential reference material for quality control laboratories to ensure the accuracy and reliability of assays for zoledronic acid and related compounds.
• Used in academic and institutional research focused on bone biology, calcium regulation, and the mechanisms of action of bisphosphonates.

Basic Information

Product Name	Zoledronic-D3 Acid
CAS No.	1134798-26-7
Molecular Formula	C5H7D3N2O7P2
Molecular Weight	278.10 g/mol (for monohydrate form)
Synonyms	Zoledronic Acid-d3; [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)-d3; 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diyldiphosphonic Acid-d3; CGP 42446-d3; ZOL-d3; Zometa-d3 (deuterated analog); (1-Hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic Acid-d3; Zoledronate-d3
EINECS	Contact for details

Quality Control

Our Zoledronic-D3 Acid is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic methods including NMR and Mass Spectrometry to confirm deuteration level and identity. Purity is determined by validated HPLC and UPLC methods. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and related substance analysis is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, a controlled room temperature of 15-25°C is recommended. Keep the container sealed in a desiccator to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Deuteration Degree (NMR)	≥ 98 atom % D
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.